I am considering some changes in my system setup. Part of that would entail moving my SuperSat 60c from it’s current shelf-mounted position and mounting it on the wall below the wall mounted tv. I know about the keyhole mounting option, but don’t the speaker wire connections get in the way? Would that solution require running the wires through the wall (something I would rather not do)?

Yes, you'd need to run the speaker wire in the wall to get the SS60C flush.

If it's OK to be about 2" out from the wall, try a pair of SuperSwivel mounts.