Hey Chris,
I am not the moderator, so, sorry if I fail to mind my own business here.
If you will use the search option, I THINK it will lead you to several threads on this forum where people have had trouble with Audyssey.
Also, if you want, you might read what Kal Rubinson, of Stereophile's column "Music in the Round" on this page:
www.stereophile.com/content/music-round-61-page-2
where he mentions a problem David Rich found with Audyssey implementation degrading Hi-Rez file playback, forcing a down-sample to 24/48 and now your Hi Rez is gone. Mr Rich talks about this on Secrets of Home Theater and High Fidelity, which I am searching to read more about it myself.
I do use Audyssey right now for my odd listening room. I have a left speaker near a left wall, and a right speaker and subwoofer on the other side with no wall at all, a whole nuther room over there.
But I am building a home theater and it will have symmetrical walls and I do not intend to use Audyssey at all if I can help it.
I guess the best thing would be to let your ears tell you what sounds the best to you.
I just always follow the "less is better" approach if I can.
Happy listening,
God Bless,
Wayne